Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL2784551 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL118155 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18981017 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL1093517 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3593172 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL674137 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4604912-A1 | NATURAL SUBSTANCE-BASED HAIR DYEING METHOD | Henkel AG & Co. KGaA (DE) | 2025-08-27 | — | — | EP | claimed |
| CN-118253761-A | Nano-micro solid silver flake capable of being sintered at low temperature and preparation method and application thereof | 深圳市百柔新材料技术有限公司 | 2024-06-28 | — | — | CN | claimed |
| WO-2024083438-A1 | NATURAL SUBSTANCE-BASED HAIR DYEING METHOD | HENKEL AG & CO. KGAA (DE) | 2024-04-25 | — | — | WO | claimed |
| CN-114914011-B | Repairing type silver-coated copper powder and preparation method thereof, electronic paste and preparation method thereof | 苏州思尔维纳米科技有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-114220588-B | HIT low-temperature silver paste for ink-jet printing and preparation method thereof | 苏州思尔维纳米科技有限公司 | 2024-02-09 | — | — | CN | claimed |
| CN-117497224-A | Sintered silver paste, sintered silver film preformed sheet and application thereof | 深圳先进电子材料国际创新研究院 | 2024-02-02 | — | — | CN | claimed |
| CN-115410749-A | Silver paste and preparation method and application thereof | 苏州诺菲纳米科技有限公司 | 2022-11-29 | — | — | CN | claimed |
| CN-115376719-A | Low-temperature silver-coated copper paste for solar cell | 苏州诺菲纳米科技有限公司 | 2022-11-22 | — | — | CN | claimed |
| CN-114914011-A | Repairing silver-coated copper powder and preparation method thereof, and electronic paste and preparation method thereof | 苏州思尔维纳米科技有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-114532359-A | Stable composition, application thereof and product containing same | 北京洁尔爽高科技有限公司 | 2022-05-27 | — | — | CN | claimed |
| EP-3028792-A1 | NANO-SILVER POWDER, THE PREPARATION METHOD AND APPLICATION IN PREPARATION OF ELECTRICALLY CONDUCTIVE INK OF THE SAME AND ELECTRICALLY CONDUCTIVE INK | Institute Of Chemistry, Chinese Academy Of Sciences (CN) | 2016-06-08 | — | — | EP | claimed |
| US-20160152851-A1 | Method for Preparing Nano-Silver Powder and Application in Preparation of Electrically Conductive Ink of the Nano-Silver Powder and Electrically Conductive Ink | INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-02 | — | — | US | claimed |
| CN-101529532-B | A silver paste for forming conductive layers | EXAX INC | 2010-12-15 | — | — | CN | claimed |
| US-20100193751-A1 | Silver Paste for Forming Conductive Layers | EXAX, Inc. | 2010-08-05 | — | — | US | claimed |
| EP-2126932-A1 | A SILVER PASTE FOR FORMING CONDUCTIVE LAYERS | Exax Inc. (KR) | 2009-12-02 | — | — | EP | claimed |
| CN-101529532-A | A silver paste for forming conductive layers | EXAX INC (KR) | 2009-09-09 | — | — | CN | claimed |
| WO-2008093913-A1 | A SILVER PASTE FOR FORMING CONDUCTIVE LAYERS | EXAX INC. (KR) | 2008-08-07 | — | — | WO | claimed |
| US-20070149792-A1 | Catalyst for epoxidation of an alkene to an alkene oxide, method of making and method of using thereof | SAUDI BASIC INDUSTRIES CORPORATION | 2007-06-28 | — | — | US | claimed |
| US-20050027133-A1 | Method of making a catalyst for direct oxidation of an alkene to an alkene oxide | SAUDI BASIC INDUSTRIES CORPORATION | 2005-02-03 | — | — | US | claimed |
| US-20050027134-A1 | Support for a catalyst for direct oxidation of propylene to propylene oxide, method of making and method of using catalyst | SAUDI BASIC INDUSTRIES CORPORATION | 2005-02-03 | — | — | US | claimed |