Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676174 | 0.81 | ALDH1A1 (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13144514 | 0.80 | MAPT (0.70) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL26986388 | 0.77 | RAB9A (0.46) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL2080499 | 0.77 | RAB9A (0.68) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL15349116 | 0.75 | RAB9A (0.56) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL676630 | 0.75 | CYP1A2 (0.44) | RAB9ANPC1MAPTPOLBGAA | |
| SCHEMBL1539569 | 0.75 | CDC7 (0.60) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL674281 | 0.75 | MAPT (0.51) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL2080725 | 0.74 | RAB9A (0.68) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL12582252 | 0.74 | RAB9A (0.72) | RAB9ANPC1MAPTPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160255-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | disclosed |
| US-20110160255-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | disclosed |
| EP-2303852-A2 | INHIBITORS OF AKT ACTIVITY | GlaxoSmithKline LLC (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009158374-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158374-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160255-A1 | INHIBITORS OF AKT ACTIVITY | AKT2, AKT1, PIK3CA | RAB9A 734/4885NPC1 4529/4885MAPT 3545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.