Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746665 | 0.78 | GSK3B (0.44) | MAPTALDH1A1KDM4ECREBBPGSK3B | |
| SCHEMBL6745220 | 0.75 | GSK3B (0.41) | POLBMAPTTP53KDM4ELMNA | |
| SCHEMBL1632272 | 0.67 | SMN1; SMN2 (0.45) | HSD17B3ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL30392101 | 0.67 | SMN1; SMN2 (0.45) | HSD17B3ALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6740554 | 0.63 | CDK2 (0.50) | ALDH1A1MEN1KMT2AGSK3B | |
| SCHEMBL6740553 | 0.63 | CDK2 (0.50) | ALDH1A1MEN1KMT2AGSK3B | |
| SCHEMBL5894137 | 0.61 | CREBBP (0.33) | POLBMAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL24186364 | 0.61 | KDM1A (0.43) | MAPTSMN1; SMN2MEN1KMT2ANR3C1 | |
| SCHEMBL4314841 | 0.61 | KCNH2 (0.47) | HSD17B3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL116463 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |