Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6745220 | 0.88 | GSK3B (0.41) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL5733322 | 0.80 | GSK3B (0.48) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL6744080 | 0.78 | POLB (0.33) | GSK3BMAPTKDM4ECREBBPALDH1A1 | |
| SCHEMBL17070929 | 0.76 | GSK3B (0.58) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL5733348 | 0.74 | SIRT2 (0.46) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL7825637 | 0.71 | GSK3B (0.77) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL320007 | 0.67 | HSD17B10 (0.53) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL154311 | 0.66 | DRD2 (0.61) | GSK3BKDM4E | |
| SCHEMBL10326494 | 0.65 | KDM4E (0.58) | GSK3BMAPTKDM4EGAACREBBP | |
| SCHEMBL6037889 | 0.65 | KDM4E (0.58) | GSK3BMAPTKDM4EGAACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |