Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746665 | 0.88 | GSK3B (0.44) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL6744080 | 0.75 | POLB (0.33) | GSK3BMAPTTP53POLBLMNA | |
| SCHEMBL5733322 | 0.69 | GSK3B (0.48) | GSK3BMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL7734085 | 0.68 | HSD17B10 (0.46) | GSK3BMAPTTP53POLBLMNA | |
| SCHEMBL154311 | 0.64 | DRD2 (0.61) | GSK3BLMNAKDM4E | |
| SCHEMBL17070929 | 0.63 | GSK3B (0.58) | GSK3BMAPTTP53KDM4EGAA | |
| SCHEMBL5733348 | 0.63 | SIRT2 (0.46) | GSK3BMAPTLMNAKDM4EGAA | |
| SCHEMBL6742680 | 0.62 | CDK2 (0.53) | — | |
| SCHEMBL26987950 | 0.62 | HTR2A (0.46) | FFAR1 | |
| SCHEMBL6600515 | 0.62 | PGR (0.47) | GSK3BMAPTTP53POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |