Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | HTR1F | P30939 | 3/20 | 0.32 |
| ▸ | HTR1B | P28222 | 2/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405794 | 0.91 | SRC (0.35) | HTR6HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL6088155 | 0.83 | CYP3A4 (0.38) | CHEK1 | |
| SCHEMBL6088559 | 0.83 | KDR (0.46) | HTR2AHTR2CCHEK1KDRFGFR1 | |
| SCHEMBL6091127 | 0.78 | KDR (0.40) | ADRA2AHTR1ASLC6A2CHEK1KDR | |
| SCHEMBL6090987 | 0.78 | CHEK1 (0.51) | CHEK1KDRAURKARETFGFR1 | |
| SCHEMBL6088913 | 0.77 | KDR (0.39) | CHEK1KDRFGFR1PDGFRBPRKAA1 | |
| SCHEMBL6088742 | 0.76 | KDM4E (0.46) | CHEK1KDRAURKARETFGFR1 | |
| SCHEMBL6090420 | 0.75 | CHEK1 (0.43) | HTR2BCHEK1KDRAURKARET | |
| SCHEMBL5358334 | 0.75 | ALDH1A1 (0.39) | CHEK1PDGFRB | |
| SCHEMBL1981272 | 0.74 | KDR (0.51) | CHEK1KDRAURKARETFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |