SCHEMBL6744741

SCHEMBL6744741

CC(C)O[SiH2]c1cccc2cc3cc4ccccc4cc3cc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.35
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 2/20 0.34
GAA P10253 2/20 0.34
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 3/20 0.32
CYP1A2 P05177 2/20 0.32
HPGD P15428 2/20 0.32
HIF1A Q16665 2/20 0.31
CYP1B1 Q16678 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
HTR2B P41595 1/20 0.31
IRAK4 Q9NWZ3 1/20 0.30
CYP3A4 P08684 1/20 0.30
UGT2B7 P16662 1/20 0.30
ERBB2 P04626 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16487309 0.82 KDM4E (0.39) ALDH1A1KDM4EMAPTHSD17B10CYP1A2
SCHEMBL6746724 0.77 ALDH1A1 (0.35) NQO1ALDH1A1KDM4EGAAMEN1
SCHEMBL16487392 0.77 HPRT1 (0.47) ALDH1A1KDM4EMAPTHSD17B10CYP1A2
SCHEMBL6750038 0.77 NQO1 (0.35) NQO1ALDH1A1KDM4EGAAMEN1
SCHEMBL2961097 0.75 ALDH1A1 (0.32) ALDH1A1L3MBTL1
SCHEMBL6746767 0.75 TDP1 (0.38) NQO1ALDH1A1HSD17B10CYP1A2HIF1A
SCHEMBL11444132 0.75 ALDH1A1 (0.41) NQO1ALDH1A1KDM4EGAAMEN1
SCHEMBL10516149 0.74 ALDH1A1 (0.40) NQO1ALDH1A1KDM4EGAAMEN1
SCHEMBL6745059 0.73 NQO1 (0.39) NQO1ALDH1A1KDM4EGAAMEN1
SCHEMBL1637897 0.73 CYP1A2 (0.32) ALDH1A1MAPTHSD17B10CYP1A2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 NQO1 2288/4885ALDH1A1 460/4885KDM4E 296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.