Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744241 | 0.90 | FEN1 (0.43) | CA1CA2FEN1PTGS2PTGS1 | |
| SCHEMBL6746852 | 0.89 | PTGS2 (0.47) | CA1CA2FEN1PTGS2PTGS1 | |
| SCHEMBL6743148 | 0.88 | PTGS2 (0.51) | CA1CA2TDP2NSD2PAX8 | |
| SCHEMBL6749480 | 0.87 | CA1 (0.40) | CA1CA2TDP2NSD2PAX8 | |
| SCHEMBL6747265 | 0.87 | CA1 (0.40) | CA1CA2TDP2NSD2PAX8 | |
| SCHEMBL6746652 | 0.87 | CA1 (0.40) | CA1CA2TDP2NSD2PAX8 | |
| SCHEMBL6746754 | 0.86 | FEN1 (0.44) | CA1CA2FEN1PTGS2PTGS1 | |
| SCHEMBL6746864 | 0.86 | FEN1 (0.42) | CA1CA2FEN1PTGS2PTGS1 | |
| SCHEMBL6746225 | 0.85 | PTGS2 (0.43) | CA1CA2TDP2NSD2PAX8 | |
| SCHEMBL6841538 | 0.85 | CA1 (0.45) | CA1CA2TDP2NSD2PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |