Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | FEN1 | P39748 | 6/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746852 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6746225 | 0.89 | PTGS2 (0.43) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6747444 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6744788 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6744241 | 0.88 | FEN1 (0.43) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6746820 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6744767 | 0.88 | CA1 (0.42) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6746754 | 0.88 | FEN1 (0.44) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6747196 | 0.86 | CA1 (0.43) | PTGS2PTGS1FEN1CA1CA2 | |
| SCHEMBL6746016 | 0.86 | RORB (0.43) | PTGS2PTGS1FEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |