Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 7/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744782 | 0.91 | CA1 (0.39) | FEN1ALOX5APCA1CA2PTGS2 | |
| SCHEMBL6747071 | 0.88 | FEN1 (0.44) | FEN1ALOX5APPTGES2CA1CA2 | |
| SCHEMBL6749867 | 0.88 | PTGS2 (0.49) | FEN1ALOX5APCA1CA2PTGS2 | |
| SCHEMBL6750040 | 0.87 | PTGS2 (0.46) | FEN1ALOX5APPTGES2CA1CA2 | |
| SCHEMBL6750085 | 0.86 | ALOX5AP (0.39) | FEN1ALOX5APCA1CA2PTGS2 | |
| SCHEMBL6743644 | 0.86 | NPC1 (0.44) | FEN1ALOX5APCA1CA2SCN9A | |
| SCHEMBL6745215 | 0.86 | FEN1 (0.45) | FEN1ALOX5APPTGS2PTGS1TGFBR1 | |
| SCHEMBL6746036 | 0.86 | FEN1 (0.40) | FEN1ALOX5APPTGES2CA1CA2 | |
| SCHEMBL6747322 | 0.86 | PTGS2 (0.50) | FEN1ALOX5APCA1CA2PTGS2 | |
| SCHEMBL6722065 | 0.86 | PTGS2 (0.43) | FEN1ALOX5APPTGES2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |