Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 9/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746459 | 0.90 | CA1 (0.40) | FEN1ALOX5APCA1CA2MAPK1 | |
| SCHEMBL6750040 | 0.89 | PTGS2 (0.46) | FEN1ALOX5APPTGES2CA1CA2 | |
| SCHEMBL6744800 | 0.88 | FEN1 (0.40) | FEN1ALOX5APPTGES2CA1CA2 | |
| SCHEMBL6743644 | 0.88 | NPC1 (0.44) | FEN1ALOX5APCA1CA2 | |
| SCHEMBL6746036 | 0.88 | FEN1 (0.40) | FEN1ALOX5APPTGES2CA1CA2 | |
| SCHEMBL6749919 | 0.88 | PTGS2 (0.47) | FEN1ALOX5APCA1CA2CA9 | |
| SCHEMBL6749461 | 0.86 | FEN1 (0.47) | FEN1ALOX5APCA1CA2 | |
| SCHEMBL6746003 | 0.86 | LMNA (0.47) | FEN1ALOX5APPTGES2MAOB | |
| SCHEMBL6745215 | 0.86 | FEN1 (0.45) | FEN1ALOX5AP | |
| SCHEMBL6718427 | 0.85 | FEN1 (0.46) | FEN1ALOX5APPTGES2CDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |