SCHEMBL6745455

SCHEMBL6745455

CC(C)=CCN1C(=O)CCC1(CCC(=O)O)CCC(=O)N[C@@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.48
ITGB1 P05556 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6740340 0.90 ITGA4 (0.41) ITGA4ITGB1
SCHEMBL6742874 0.88 ITGA4 (0.52) ITGA4ITGB1
SCHEMBL6743762 0.78 ITGA4 (0.51) ITGA4ITGB1
SCHEMBL6741689 0.75 ITGA4 (0.52) ITGA4ITGB1
SCHEMBL6741692 0.75 ITGA4 (0.52) ITGA4ITGB1
SCHEMBL6741757 0.71 ITGB1 (0.57) ITGA4ITGB1
SCHEMBL6744662 0.71 ITGA4 (0.46) ITGA4ITGB1
SCHEMBL6744659 0.71 ITGA4 (0.46) ITGA4ITGB1
SCHEMBL3722480 0.69 ITGA4 (0.67) ITGA4ITGB1
SCHEMBL3722481 0.69 ITGA4 (0.67) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6685617-B1 4-(((-1-CARBOXY-2-(4-((2,6-DICHLOROBENZOYL)AMINE)PHENYL)ETHYL) AMINO)CARBONYL)-3-OXO-3-THIAZOLIDINEBUTANOIC ACID, USED AS ANTAGONISTS FOR CELLULAR ADHESION MOLECULES, AND ADMINISTERED AS ANTIINFLAMMATORY AGENTS PHARMACIA & UPJOHN COMPANY 2004-02-03 US disclosed