SCHEMBL6746219

SCHEMBL6746219

CC(=O)Nc1cc2ccccc2c2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.59
KDM4E B2RXH2 6/20 0.59
CYP1A2 P05177 4/20 0.59
KMT2A Q03164 3/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
CYP2D6 P10635 2/20 0.59
CYP2C19 P33261 2/20 0.59
MEN1 O00255 2/20 0.59
CYP2C9 P11712 2/20 0.59
CYP3A4 P08684 1/20 0.59
ALOX12 P18054 1/20 0.59
RXFP1 Q9HBX9 1/20 0.54
GLA P06280 1/20 0.54
GAA P10253 1/20 0.54
HPGD P15428 4/20 0.53
LMNA P02545 1/20 0.53
MAOA P21397 1/20 0.53
HSD17B10 Q99714 1/20 0.53
IDO1 P14902 2/20 0.53
PPM1A P35813 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6138950 0.88 HPRT1 (0.66) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL13609731 0.83 ALDH1A1 (0.53) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL9464673 0.82 CDC25B (0.55) ALDH1A1KDM4ECYP1A2SMN1; SMN2CYP2C19
SCHEMBL6691636 0.82 POLB (0.57) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL11662771 0.82 MEN1 (0.59) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL8982554 0.82 KDM4E (0.63) ALDH1A1KDM4ECYP1A2KMT2ACYP2D6
SCHEMBL7527927 0.82 KDM4E (0.61) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL14503713 0.81 POLB (0.49) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL31154593 0.78 ALDH1A1 (0.58) ALDH1A1KDM4ECYP1A2KMT2ASMN1; SMN2
SCHEMBL6138266 0.77 MAPT (0.60) ALDH1A1KDM4ECYP1A2KMT2ACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040126892-A1 Methods for characterizing a mixture of chemical compounds ADVANCED CHEMISTRY DEVELOPMENT (CA) 2004-07-01 US disclosed