Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 4/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
| ▸ | RPS27 | P42677 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746295 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL231183 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL231181 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL6750050 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL6187189 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL231182 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL6185529 | 0.91 | CYP2D6 (0.40) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL6748041 | 0.87 | CYP2D6 (0.39) | CYP2D6SLC6A2SLC6A4NOS2AR | |
| SCHEMBL6188753 | 0.85 | CYP2D6 (0.42) | CYP2D6SLC6A2SLC6A4NOS2MAPT | |
| SCHEMBL6750954 | 0.84 | CYP2D6 (0.42) | CYP2D6SLC6A2SLC6A4NOS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | claimed |
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | CYP1A1, NOS3, NOS1 | CYP2D6 48/4885SLC6A2 2580/4885SLC6A4 1815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.