Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743835 | 0.92 | PTGS2 (0.55) | PTGS2PTGS1KMO | |
| SCHEMBL6723228 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1SCN9AKMOCYP2C9 | |
| SCHEMBL6750081 | 0.87 | PTGS1 (0.45) | PTGS2PTGS1KMOFEN1ALOX5AP | |
| SCHEMBL6742763 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1SCN9AKMOCYP2C9 | |
| SCHEMBL6837556 | 0.85 | PTGS2 (0.47) | PTGS2PTGS1SCN9ACYP2C9DYRK1A | |
| SCHEMBL6746048 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1KMOFEN1ALOX5AP | |
| SCHEMBL6746792 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1SCN9ACYP2C9DYRK1A | |
| SCHEMBL6836566 | 0.83 | PTGS2 (0.50) | PTGS2PTGS1SCN9ACYP2C9 | |
| SCHEMBL7048176 | 0.83 | KMO (0.45) | PTGS2PTGS1SCN9AKMOCYP2C9 | |
| SCHEMBL6747444 | 0.82 | PTGS2 (0.44) | PTGS2PTGS1KMOFEN1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |