Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | BMX | P51813 | 1/20 | 0.47 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.46 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.45 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193515 | 1.00 | AURKA (0.57) | AURKARPS6KB1EGFRHPGDSAURKB | |
| SCHEMBL8930214 | 0.93 | AURKA (0.59) | AURKARPS6KB1EGFRHPGDSAURKB | |
| Hydrochloric Acid SCHEMBL8929656 | 0.91 | AURKA (0.58) | AURKARPS6KB1EGFRHPGDSAURKB | |
| SCHEMBL8929331 | 0.81 | HPGDS (0.48) | AURKARPS6KB1EGFRHPGDSAURKB | |
| SCHEMBL22524329 | 0.81 | AURKA (0.56) | AURKARPS6KB1EGFRAURKBJAK2 | |
| SCHEMBL22524331 | 0.81 | AURKA (0.56) | AURKARPS6KB1EGFRAURKBJAK2 | |
| SCHEMBL9038194 | 0.80 | EGFR (0.67) | AURKARPS6KB1EGFRAURKBNAE1 | |
| SCHEMBL19010748 | 0.80 | FADS1 (0.45) | AURKARPS6KB1EGFRCA2CA1 | |
| Hydrochloric Acid SCHEMBL8929839 | 0.80 | HPGDS (0.47) | AURKARPS6KB1EGFRHPGDSAURKB | |
| SCHEMBL8929835 | 0.80 | HPGDS (0.63) | HPGDSIRAK4TTBK1TTBK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703421-B1 | ADMINISTERING NF-KAPPA B INHIBITOR | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2004-03-09 | — | — | US | disclosed |