Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904573 | 0.81 | CYP1A2 (0.43) | SLC6A4ARRIPK1GAAPOLB | |
| SCHEMBL7769554 | 0.80 | DPP4 (0.63) | DPP4ARGAAPOLBHRH1 | |
| SCHEMBL6748651 | 0.79 | SLC6A4 (0.46) | DPP4SLC6A4ARSLC6A2RIPK1 | |
| SCHEMBL954804 | 0.78 | TSHR (0.41) | ARCYP1A2CYP2C19 | |
| SCHEMBL6746669 | 0.77 | DPP4 (0.46) | DPP4SLC6A4SLC6A2RIPK1ELANE | |
| SCHEMBL4824572 | 0.75 | HRH1 (0.55) | DPP4SLC6A4SLC6A2RIPK1GAA | |
| SCHEMBL10549089 | 0.74 | TTR (0.44) | SLC6A4ARBRD4SMN1; SMN2HTR2A | |
| SCHEMBL232763 | 0.73 | SMN1; SMN2 (0.56) | SLC6A4ARSLC6A2RIPK1GAA | |
| SCHEMBL11173106 | 0.73 | MEN1 (0.44) | SLC6A4SLC6A2RIPK1GAAPOLB | |
| SCHEMBL2339526 | 0.72 | DHFR (0.54) | DPP4SLC6A4SLC6A2RIPK1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040087583-A1 | Amino-thio-acrylonitriles as MEK inhibitors | HOBBS FRANK WORDEN (US) | 2004-05-06 | — | — | US | disclosed |
| US-6703420-B1 | MITOGEN ACTIVATED PROTEIN KINASE (MAPK) INHIBITORS; ANTIINFLAMMATORY, ANTICARCINOGENIC, OR ANTIPROLIFERATIVE AGENTS; RADIOSENSITIZERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-09 | — | — | US | disclosed |
| EP-1163215-A1 | AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056706-A1 | AMINO-THIO-ACRYLONITRILES AS MEK INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087583-A1 | Amino-thio-acrylonitriles as MEK inhibitors | MAPK1, MAP3K1, CDKN1A | DPP4 4302/4885SLC6A4 4629/4885AR 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.