Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMOX | Q9NWM0 | 2/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14098008 | 0.81 | DPP4 (0.42) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL6746682 | 0.80 | DPP4 (0.42) | DPP4POLBGAAHRH1AR | |
| SCHEMBL956649 | 0.79 | NPC1 (0.41) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL31447072 | 0.79 | NPC1 (0.41) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL779716 | 0.78 | TAAR1 (0.44) | LMNAGAANPSR1TDP1 | |
| SCHEMBL14382784 | 0.77 | DPP4 (0.69) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL112755 | 0.77 | DPP4 (1.00) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL1191734 | 0.77 | DPP4 (0.69) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL7765693 | 0.77 | DPP4 (0.69) | DPP4MAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL14452021 | 0.77 | DPP4 (0.63) | DPP4MAPTLMNAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1216052-C | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenz (b,f) oxepines | NAVARTIS AG (CH) | 2005-08-24 | — | — | CN | disclosed |
| EP-0726265-B1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | NOVARTIS AG (CH) | 2001-07-25 | — | — | EP | disclosed |
| US-5780501-A | ADMINISTERING TO A MAMMAL | NOVARTIS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| US-5780500-A | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenzi b,f! oxepines | NOVARTIS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| CN-1137039-A | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenz (b,f) oxepines | CIBA GEIGY AG (CH) | 1996-12-04 | — | — | CN | disclosed |
| EP-0726265-A1 | 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity | CIBA-GEIGY AG (CH) | 1996-08-14 | — | — | EP | disclosed |