Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.68 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494012 | 0.87 | TOP2A (0.78) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8485606 | 0.81 | TOP2A (0.42) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL7496668 | 0.79 | TOP2A (0.79) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8487670 | 0.78 | TOP2A (0.41) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8485863 | 0.76 | TOP2A (0.43) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL7493287 | 0.71 | TOP2A (0.80) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8483875 | 0.70 | KDM1A (0.34) | TOP2ATOP2BSMN1; SMN2KDM4E | |
| SCHEMBL11748467 | 0.70 | TOP2A (0.57) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8485482 | 0.68 | NQO1 (0.41) | TOP2ATOP2BPOLBNPC1HTT | |
| SCHEMBL8482764 | 0.67 | TOP2A (0.34) | TOP2ATOP2BSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747039-B2 | INHIBITING CELL PROLIFERATION IN MAMMALS | ALBANY MOLECULAR RESEARCH, INC. | 2004-06-08 | — | — | US | disclosed |