Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 11/20 | 0.78 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747123 | 0.87 | TOP2A (0.68) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL7496668 | 0.86 | TOP2A (0.79) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL7493287 | 0.84 | TOP2A (0.80) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL11748467 | 0.83 | TOP2A (0.57) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL7495129 | 0.80 | TOP2A (0.50) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL7488073 | 0.80 | TOP2A (0.50) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10925309 | 0.79 | TOP2A (0.49) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL7503128 | 0.79 | TOP2A (0.49) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL10815975 | 0.78 | TOP2A (0.49) | TOP2ATOP2BPOLBHTTSMN1; SMN2 | |
| SCHEMBL10811524 | 0.77 | TOP2A (0.52) | TOP2ATOP2BPOLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812192-B1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI SYNTHELABO (FR) | 2002-11-06 | — | — | EP | claimed |
| EP-0812192-A4 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP INC (US) | 2000-03-08 | — | — | EP | claimed |
| EP-0812192-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1997-12-17 | — | — | EP | claimed |
| WO-1996026723-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1996-09-06 | — | — | WO | claimed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | claimed |
| EP-0812192-B1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI SYNTHELABO (FR) | 2002-11-06 | — | — | EP | disclosed |
| EP-0812192-A4 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0812192-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026723-A1 | BENZOTHIOPYRANOINDAZOLES ANTITUMOR AGENTS | SANOFI WINTHROP, INC. (US) | 1996-09-06 | — | — | WO | disclosed |
| US-5532263-A | Benzothiopyranoindazole antitumor agents | STERLING WINTHROP INC. (US) | 1996-07-02 | — | — | US | disclosed |