SCHEMBL6747168

SCHEMBL6747168

c1csc(C2CCCS2)c1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 4/20 0.54
BRDT Q58F21 1/20 0.50
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
LMNA P02545 3/20 0.36
BCHE P06276 1/20 0.36
TSHR P16473 2/20 0.35
KDM4E B2RXH2 2/20 0.35
HTT P42858 1/20 0.35
ALDH1A1 P00352 3/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
GAA P10253 2/20 0.34
POLB P06746 1/20 0.34
HPGD P15428 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6131523 0.94 BRD4 (0.53) BRD4BRDTMAPTSMN1; SMN2LMNA
SCHEMBL19512122 0.90
SCHEMBL8648117 0.76 BRD4 (0.47) BRD4BRDTMAPTSMN1; SMN2BCHE
SCHEMBL145927 0.75 MAPT (0.39) BRD4BRDTMAPTSMN1; SMN2LMNA
SCHEMBL7468907 0.74 BRD4 (0.44) BRD4BRDTMAPTSMN1; SMN2LMNA
SCHEMBL8648121 0.73 MAOA (0.46) BRD4BRDTMAPTSMN1; SMN2BCHE
SCHEMBL498606 0.72 MAPT (0.47) BRD4MAPTSMN1; SMN2LMNATSHR
SCHEMBL8133890 0.72
SCHEMBL497608 0.71
SCHEMBL663162 0.70 MAPT (0.46) MAPTSMN1; SMN2LMNATSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696216-B2 A PHOTO ACID GENERATOR USED IN GENERATING AN ACID FOR CHEMICALLY CLEAVING ACID SENSITIVE SIDE CHAINS OF A CHEMICALLY AMPLIFIED BASE POLYMER CONTAINS A SULFONIUM OR IODONIUM SALT CONTAINING ATLEAST ONE THIOPHENE RING INTERNATIONAL BUSINESS MACHINES CORPORATION 2004-02-24 US claimed
US-20030008230-A1 Thiophene-containing photo acid generators for photolithography INTERNATIONAL BUSINESS MACHINES CORPORATION 2003-01-09 US claimed
WO-2003003120-A1 THIOPHENE-CONTAINING PHOTO ACID GENERATORS FOR PHOTOLITHOGRAPHY INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2003-01-09 WO claimed
US-5210088-A Treating pain with tetrahydroisoquinoline derivatives JOHN WYETH & BROTHER, LIMITED (GB) 1993-05-11 US claimed
US-5118690-A PHARMACEUTICAL TETRAHYDROISOQUINOLINES JOHN WYETH & BROTHER LIMITED (GB) 1992-06-02 US claimed
EP-0419247-A2 Selective GABA antagonists, especially isoquinoline derivatives, and their use for treating CNS disorders JOHN WYETH & BROTHER LIMITED (GB) 1991-03-27 EP claimed
CN-112399873-B Triazole glycolate oxidase inhibitors 坎特罗治疗有限公司 2024-10-25 CN disclosed
CN-112236416-B Pyrimidine cyclohexenyl glucocorticoid receptor modulators 科赛普特治疗公司 2024-03-01 CN disclosed
CN-114605387-A Substituted benzimidazoles, their preparation and their use as medicaments 埃皮吉纳提克斯股份有限公司 2022-06-10 CN disclosed
CN-108137539-B Substituted benzimidazoles, their preparation and their use as pharmaceuticals 尼奥迈德研究所 2022-01-11 CN disclosed
US-6696216-B2 A PHOTO ACID GENERATOR USED IN GENERATING AN ACID FOR CHEMICALLY CLEAVING ACID SENSITIVE SIDE CHAINS OF A CHEMICALLY AMPLIFIED BASE POLYMER CONTAINS A SULFONIUM OR IODONIUM SALT CONTAINING ATLEAST ONE THIOPHENE RING INTERNATIONAL BUSINESS MACHINES CORPORATION 2004-02-24 US disclosed
US-20030008230-A1 Thiophene-containing photo acid generators for photolithography INTERNATIONAL BUSINESS MACHINES CORPORATION 2003-01-09 US disclosed
WO-2003003120-A1 THIOPHENE-CONTAINING PHOTO ACID GENERATORS FOR PHOTOLITHOGRAPHY INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2003-01-09 WO disclosed
US-5861421-A 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds SMITHKLINE BEECHAM CORPORATION (US) 1999-01-19 US disclosed