Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 10/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 9/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746002 | 0.92 | PTGS2 (0.41) | FEN1ALOX5APPTGS1PTGS2SCN9A | |
| SCHEMBL6723491 | 0.89 | PTGS1 (0.39) | FEN1ALOX5APPTGS1PTGS2SCN9A | |
| SCHEMBL6839124 | 0.86 | PTGS2 (0.36) | PTGS1PTGS2SCN9ACYP2C9SCN5A | |
| SCHEMBL6746864 | 0.86 | FEN1 (0.42) | FEN1ALOX5APPTGS1PTGS2TGFBR1 | |
| SCHEMBL6747442 | 0.85 | PTGS2 (0.49) | FEN1ALOX5APPTGS1PTGS2TGFBR1 | |
| SCHEMBL6746250 | 0.84 | FEN1 (0.39) | FEN1ALOX5APPTGS1PTGS2SCN9A | |
| SCHEMBL6837154 | 0.84 | CA1 (0.41) | PTGS1PTGS2SCN9ATGFBR1CYP2C9 | |
| SCHEMBL6745515 | 0.84 | ALOX5AP (0.38) | FEN1ALOX5APPTGS1PTGS2SCN9A | |
| SCHEMBL6746673 | 0.84 | PTGS2 (0.42) | FEN1ALOX5APPTGS1PTGS2SCN9A | |
| SCHEMBL7046231 | 0.84 | SYK (0.40) | FEN1ALOX5APPTGS1PTGS2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |