Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678710 | 1.00 | TP53 (0.40) | TP53HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL675181 | 0.92 | NFE2L2 (0.40) | TP53HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL676360 | 0.91 | HDAC3 (0.44) | TP53HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3667601 | 0.87 | TP53 (0.41) | TP53HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3668236 | 0.82 | HTR6 (0.46) | SRCPPARGPPARDPPARAHTR6 | |
| SCHEMBL675280 | 0.82 | HTR6 (0.44) | MAPTSRCSMN1; SMN2PPARGPPARD | |
| SCHEMBL679195 | 0.81 | SRC (0.40) | TP53HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL675484 | 0.81 | SRC (0.40) | TP53HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL676108 | 0.80 | HTR2A (0.43) | TP53MAPTSRCSMN1; SMN2HTR6 | |
| SCHEMBL676193 | 0.80 | SRC (0.39) | SRCPPARGPPARDPPARAHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | claimed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | claimed |
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | ALK, BCR, NPM1 | TP53 243/4885HDAC3 3179/4885HDAC4 3975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.