Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eprosartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 2/20 | 0.98 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.98 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eprosartan SCHEMBL6747993 | 1.00 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL4025 | 0.99 | AGTR1 (1.00) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL4026 | 0.99 | AGTR1 (1.00) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL1815060 | 0.99 | AGTR1 (1.00) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL156290 | 0.99 | AGTR1 (1.00) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL7405236 | 0.98 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL1119965 | 0.98 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL7405237 | 0.98 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL1119964 | 0.98 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL1897811 | 0.98 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040028582-A1 | Crystallization process for producing fine crystal products | SMITHKLINE BEECHAM CORPORATION | 2004-02-12 | — | — | US | disclosed |
| EP-1165197-A1 | CRYSTALLIZATION PROCESS FOR PRODUCING FINE CRYSTAL PRODUCTS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000053282-A1 | CRYSTALLIZATION PROCESS FOR PRODUCING FINE CRYSTAL PRODUCTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-09-14 | — | — | WO | disclosed |