Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26246 | 0.75 | MMP3 (0.74) | MMP3NOTUMKIF11CA12CA2 | |
| Water SCHEMBL11055485 | 0.75 | MMP3 (0.74) | MMP3NOTUMKIF11CA12CA2 | |
| SCHEMBL13063633 | 0.75 | MMP3 (0.74) | MMP3NOTUMKIF11CA12CA2 | |
| SCHEMBL396846 | 0.75 | MMP3 (0.74) | MMP3NOTUMKIF11CA12CA2 | |
| SCHEMBL16789941 | 0.73 | MMP3 (0.64) | MMP3NOTUMKIF11CA12CA2 | |
| SCHEMBL3611983 | 0.73 | MMP3 (0.64) | MMP3NOTUMKIF11CA12CA2 | |
| SCHEMBL6750099 | 0.72 | GAA (0.45) | TNKSCA12CA2CA9CYP2A6 | |
| Methane SCHEMBL28372042 | 0.72 | MMP3 (0.70) | MMP3NOTUMKIF11CA12CA2 | |
| SCHEMBL2901045 | 0.72 | TSHR (0.44) | NOTUMTNKSMYCCYP2A6ALDH1A1 | |
| SCHEMBL674221 | 0.72 | CHRM2 (0.50) | MMP3NOTUMTNKSCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1130019-B1 | 2,4-bis((4-Amidino)phenyl)furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-0941991-B1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1130019-A1 | 2,4-bis((4-Amidino)phenyl)furans as anti-pneumocystis carinii agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6127554-A | MAKING 2,4-BIS(HALO-PHENYL)FURAN COMPOUNDS BY REACTING 2,4-BIS(HALO-PHENYL),5-((HALO-PHENYL)CARBONYL)FURAN IN THE PRESENCE OF A BASE; CHEMICAL INTERMEDIATE TO SYNTHESIS OF ANTIMICROBIAL AGENT | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-10-03 | — | — | US | disclosed |
| JP-2000256343-A | 2,4-BIS[(4-AMIDINO)PHENYL]FURAN AS ANTI-PNEUMOCYSTIS CARINI PNEUMONIC AGENT | UNIV NORTH CAROLINA AT CHAPEL HILL:THE | 2000-09-19 | — | — | JP | disclosed |
| US-6008247-A | TREATING PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0941991-A1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-09-15 | — | — | EP | disclosed |