SCHEMBL6748568

SCHEMBL6748568

CON(C(C)=O)c1c(SC(F)(F)F)c(C#N)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRB3 P28472 19/20 0.44
GABRP O00591 18/20 0.44
GABRD O14764 18/20 0.44
GABRA1 P14867 18/20 0.44
GABRB1 P18505 18/20 0.44
GABRG2 P18507 18/20 0.44
GABRA5 P31644 18/20 0.44
GABRA3 P34903 18/20 0.44
GABRA2 P47869 18/20 0.44
GABRB2 P47870 18/20 0.44
GABRA4 P48169 18/20 0.44
GABRE P78334 18/20 0.44
GABRA6 Q16445 18/20 0.44
GABRG1 Q8N1C3 18/20 0.44
GABRG3 Q99928 18/20 0.44
GABRQ Q9UN88 18/20 0.44
NR1I2 O75469 1/20 0.44
LMNA P02545 1/20 0.44
CYP3A4 P08684 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9010451 0.91 GABRP (0.45) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL9010476 0.90 GABRB3 (0.43) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL9010533 0.90 GABRB3 (0.42) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL9010475 0.88 GABRB3 (0.45) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL6788781 0.87 GABRB3 (0.46) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL9010489 0.87 GABRB3 (0.40) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL6055889 0.86 GABRB3 (0.44) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL9010497 0.85 GABRB3 (0.43) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL6055815 0.84 GABRB3 (0.47) GABRB3GABRPGABRDGABRA1GABRB1
SCHEMBL5857881 0.83 GABRB3 (0.41) GABRB3GABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5556873-A AGRICULTURAL PESTICIDES RHONE-POULENC INC. (US) 1996-09-17 US claimed
JP-10007509-A None JP disclosed
US-20040010016-A1 Control of arthropods in animals AVENTIS CROPSCIENCE, S.A. (FR) 2004-01-15 US disclosed
US-6630499-B1 Non-emetic 1-arylpyrazole for oral administration AVENTIS CROPSCIENCE, S.A. (FR) 2003-10-07 US disclosed
US-6531501-B1 Veterinary parasiticide AVENTIS CROPSCIENCE, S.A. (FR) 2003-03-11 US disclosed
JP-H107509-A NEW AGROCHEMICAL RHONE POULENC AGROCHIM 1998-01-13 JP disclosed
EP-0811615-A1 1-Aryl-5-(substituted alkyl (thio) amido) pyrazoles and their use as pesticides RHONE-POULENC AGROCHIMIE (FR) 1997-12-10 EP disclosed
US-5556873-A AGRICULTURAL PESTICIDES RHONE-POULENC INC. (US) 1996-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040010016-A1 Control of arthropods in animals CTRL, CYP3A43, RPL41 GABRB3 1493/4885GABRP 2380/4885GABRD 1148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.