SCHEMBL6748735

SCHEMBL6748735

c1ccc(CC2CNC3CCCC2C3)cc1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.42
GBA1 P04062 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6941270 0.77 GBA1 (0.42) POLBGBA1
SCHEMBL27775180 0.71 MAOB (0.39)
SCHEMBL15755799 0.69 F2 (0.44) POLBGBA1
SCHEMBL20561186 0.69 POLB (0.44) POLB
Hydrochloric Acid SCHEMBL5696802 0.67 SLC1A2 (0.43) POLBGBA1
Hydrochloric Acid SCHEMBL6447076 0.67 SLC1A2 (0.43) POLBGBA1
SCHEMBL16241618 0.67 HPGD (0.46) GBA1
SCHEMBL28954933 0.67 POLB (0.52) POLBGBA1
SCHEMBL11474633 0.66 GBA1 (0.53) POLBGBA1
SCHEMBL10794275 0.66 HSD11B1 (0.46) POLBGBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101321554-A Transdermal drug delivery systems, devices, and methods employing opioid agonist and/or opioid antagonist TTI ELLEBEAU INC (JP) 2008-12-10 CN claimed
CN-1166640-C Substituted 1,2,3,4,5, 6-hexahydro-2, 6-methano-3-benzazocin-10-ols, process for their preparation and their use as pharmaceutical compositions ���ָ��Ӣ��ķ�������Ϲ�˾ 2004-09-15 CN claimed
CN-1125053-C Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R, 5S, 2'R')-3'-hydroxy-2-(2-methoxypropyl)-5,..... BOEHRINGER INGELHEIM KG (DE) 2003-10-22 CN claimed
CN-103405431-B Opioid and opioid-like compounds and uses thereof Taiwan J Pharmaceutical Co.,Ltd. (CN) 2016-04-13 CN disclosed
CN-103405431-A Opioid and opioid-like compounds and uses thereof JENKEN BIOSCIENCES INC 2013-11-27 CN disclosed
CN-103394090-A Opioids for treatment of restless leg syndrome (RLS) EURO CELTIQUE SA 2013-11-20 CN disclosed
CN-1653050-B Opioid and opioid-like compounds and uses thereof JENKEN BIOSCIENCES INC 2013-04-24 CN disclosed
CN-1984658-B Opioids for the treatment of Chronic Obstructive Pulmonary Disease (COPD) EURO CELTIQUE SA 2012-04-18 CN disclosed
CN-101321554-A Transdermal drug delivery systems, devices, and methods employing opioid agonist and/or opioid antagonist TTI ELLEBEAU INC (JP) 2008-12-10 CN disclosed
CN-1984658-A Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) EURO CELTIQUE SA (LU) 2007-06-20 CN disclosed
CN-1984659-A Opioids for the treatment of Restless Leg Syndrome (RLS) EURO CELTIQUE SA (LU) 2007-06-20 CN disclosed
CN-1653050-A Opioid and opioid-like compounds and uses thereof JENKEN BIOSCIENCES INC (US) 2005-08-10 CN disclosed
CN-1166640-C Substituted 1,2,3,4,5, 6-hexahydro-2, 6-methano-3-benzazocin-10-ols, process for their preparation and their use as pharmaceutical compositions ���ָ��Ӣ��ķ�������Ϲ�˾ 2004-09-15 CN disclosed
WO-2003026635-A3 IMPROVED METHOD OF TREATING THE SYNDROME OF TYPE 2 DIABETES IN HUMANS CPD LLC (US) 2004-04-01 WO disclosed
CN-1125053-C Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R, 5S, 2'R')-3'-hydroxy-2-(2-methoxypropyl)-5,..... BOEHRINGER INGELHEIM KG (DE) 2003-10-22 CN disclosed
WO-2003026635-A2 IMPROVED METHOD OF TREATING THE SYNDROME OF TYPE 2 DIABETES IN HUMANS CPD, LLC (US) 2003-04-03 WO disclosed
CN-1269790-A Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-oles, method for production and use thereof as medicaments BOEHRINGER INGELHEIM PHARMA (DE) 2000-10-11 CN disclosed
WO-1999003347-A1 METHOD FOR TREATING NICOTINE ADDICTION ALBANY MEDICAL COLLEGE (US) 1999-01-28 WO disclosed
CN-1190959-A New process for preparing pharmaceutically useful benzomorphane derivatives, particularly (-) - (1R,5S,2' ' -R) -3 ' -hydroxy-2- (2-methoxypropyl) -5, 9, 9-trimethyl-6, 7-benzomorphane intermediates, norbenzomorphane BOEHRINGER INGELHEIM KG (DE) 1998-08-19 CN disclosed
WO-1997042950-A1 METHOD FOR TREATING COCAINE AND AMPHETAMINE DEPENDENCY ALBANY MOLECULAR RESEARCH, INC. (US) 1997-11-20 WO disclosed