Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946697 | 0.85 | REN (0.39) | — | |
| SCHEMBL5870697 | 0.79 | SLC6A2 (0.40) | — | |
| SCHEMBL6748735 | 0.77 | POLB (0.42) | GBA1POLB | |
| SCHEMBL9115414 | 0.74 | HSD11B1 (0.42) | GBA1 | |
| SCHEMBL16241618 | 0.73 | HPGD (0.46) | GBA1 | |
| SCHEMBL23477686 | 0.70 | GBA1 (0.42) | GBA1 | |
| SCHEMBL25787275 | 0.70 | — | — | |
| SCHEMBL7678641 | 0.69 | GBA1 (0.46) | GBA1 | |
| SCHEMBL6944306 | 0.69 | GBA1 (0.46) | GBA1 | |
| SCHEMBL6944308 | 0.69 | GBA1 (0.46) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248617-A4 | 2-AZA-BICYCLO 2.2.2]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6489477-B1 | NMDA NR2B ANTAGONISTS. ACCORDINGLY, ANOTHER ASPECT OF THE INVENTION IS THE TREATMENT OF PAIN, MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE--MALADIES THAT ARE AMENABLE TO AMELIORATION THROUGH | MERCK & CO., INC. | 2002-12-03 | — | — | US | disclosed |
| EP-1248617-A1 | 2-AZA-BICYCLO 2.2.2]OCTANE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001032177-A1 | 2-AZA-BICYCLO[2.2.2]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |