Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 15/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.75 |
| ▸ | CCR2 | P41597 | 1/20 | 0.75 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5675524 | 0.97 | CXCR4 (0.71) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL1259323 | 0.95 | CXCR4 (0.67) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL675084 | 0.95 | CXCR4 (0.67) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL17929341 | 0.95 | CXCR4 (0.72) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL674847 | 0.93 | CXCR4 (0.65) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| Bromide SCHEMBL7495511 | 0.93 | CXCR4 (0.68) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL29823861 | 0.92 | CXCR4 (0.69) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| Bromide SCHEMBL1259133 | 0.92 | CXCR4 (0.66) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL21961925 | 0.91 | SIGMAR1 (0.71) | CXCR4TDP1MEN1CHRM2CHRM1 | |
| SCHEMBL1259602 | 0.91 | SIGMAR1 (0.71) | CXCR4TDP1MEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210161859-A1 | USE OF CXCR4 ANTAGONISTS | University of Washington Center for Commercialization | 2021-06-03 | — | — | US | claimed |
| US-20150030561-A1 | Use of CXCR4 Antagonists | GENZYME CORP. (US) | 2015-01-29 | — | — | US | claimed |
| EP-2391211-A1 | METHODS AND COMPOSITIONS FOR TREATING BREAST CANCER | Genzyme Corporation (US) | 2011-12-07 | — | — | EP | claimed |
| US-20110280827-A1 | METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES | HU YANPING (US) | 2011-11-17 | — | — | US | claimed |
| US-20110281814-A1 | METHODS AND COMPOSITIONS FOR TREATING BREAST CANCER | GENZYME CORPORATION | 2011-11-17 | — | — | US | claimed |
| EP-2384115-A1 | METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES | Genzyme Corporation (US) | 2011-11-09 | — | — | EP | claimed |
| EP-2371361-A1 | Methods to mobilize progenitor/stem cells | Genzyme Global S.à.r.l. (LU) | 2011-10-05 | — | — | EP | claimed |
| US-7935692-B2 | Methods to mobilize progenitor/stem cells | GENZYME CORPORATION (US) | 2011-05-03 | — | — | US | claimed |
| US-RE42152-E1 | Aromatic-linked polyamine macrocyclic compounds with anti-HIV activity | GENZYME CORPORATION (US) | 2011-02-15 | — | — | US | claimed |
| WO-2010088398-A1 | METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES | GENZYME CORPORATION (US) | 2010-08-05 | — | — | WO | claimed |
| US-20020058653-A1 | Methods to enhance white blood cell count | ANORMED, INC. (CA) | 2002-05-16 | — | — | US | claimed |
| EP-1133291-A4 | METHODS OF TREATING THROMBOCYTOPENIA | SMITHKLINE BEECHAM CORP (US) | 2002-05-02 | — | — | EP | claimed |
| US-6365583-B1 | ADMINISTERING NITROGEN CONTAINING CYCLIC COMPOUNDS FOR THERAPY OF ENHANCING WHITE BLOOD CELL COUNT | ANORMED, INC. | 2002-04-02 | — | — | US | claimed |
| EP-1148875-A1 | METHODS AND COMPOSITIONS TO ENHANCE WHITE BLOOD CELL COUNT | ANORMED INC. (CA) | 2001-10-31 | — | — | EP | claimed |
| EP-1133291-A1 | METHODS OF TREATING THROMBOCYTOPENIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-19 | — | — | EP | claimed |
| WO-2000045814-A1 | METHODS AND COMPOSITIONS TO ENHANCE WHITE BLOOD CELL COUNT | ANORMED INC. (CA) | 2000-08-10 | — | — | WO | claimed |
| WO-2000028987-A1 | METHODS OF TREATING THROMBOCYTOPENIA | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-25 | — | — | WO | claimed |
| US-5583131-A | FOR TREATMENT OR PREVENTION OF ACQUIRED IMMUNE DEFICIENCY SYNDROME, REDUCED TOXICITY | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1996-12-10 | — | — | US | claimed |
| EP-0619813-A1 | LINKED CYCLIC POLYAMINES WITH ACTIVITY AGAINST HIV | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1994-10-19 | — | — | EP | claimed |
| WO-1993012096-A1 | LINKED CYCLIC POLYAMINES WITH ACTIVITY AGAINST HIV | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1993-06-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210161859-A1 | USE OF CXCR4 ANTAGONISTS | CXCR4, CXCR2, CXCR3 | CXCR4 1/4885TDP1 3497/4885MEN1 3707/4885 |
| US-20150030561-A1 | Use of CXCR4 Antagonists | CXCR4, CXCR2, CXCR3 | CXCR4 1/4885TDP1 3497/4885MEN1 3707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.