Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089234 | 0.85 | DYRK1A (0.64) | HDAC1DYRK1ACLK4PIK3CGCAMKK2 | |
| SCHEMBL4892013 | 0.82 | KMO (0.57) | HDAC1PIK3CGCAMKK2MAPK8MAPT | |
| SCHEMBL1064494 | 0.82 | HDAC1 (1.00) | HDAC1HDAC3NCOR1HDAC2HDAC8 | |
| SCHEMBL959130 | 0.81 | PTGDR (0.64) | HDAC1DYRK1ACLK4PIK3CGCAMKK2 | |
| SCHEMBL211742 | 0.80 | SMN1; SMN2 (0.53) | HDAC1NR1H4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2733584 | 0.80 | HDAC1 (0.55) | HDAC1DYRK1ACLK4PIK3CGCAMKK2 | |
| SCHEMBL8348225 | 0.79 | DYRK1A (0.67) | HDAC1DYRK1ACLK4PIK3CGDYRK1B | |
| SCHEMBL8279955 | 0.78 | HDAC1 (0.50) | HDAC1DYRK1ACLK4PIK3CGCAMKK2 | |
| SCHEMBL5092092 | 0.78 | CLK4 (0.69) | HDAC1DYRK1ACLK4PIK3CGCAMKK2 | |
| SCHEMBL5092238 | 0.77 | CAMKK2 (0.60) | HDAC1DYRK1ACLK4PIK3CGCAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072770-A1 | Methods for specifically inhibiting histone deacetylase-7 and 8 | METHYLGENE, INC. (CA) | 2004-04-15 | — | — | US | disclosed |
| WO-2004005513-A2 | METHODS FOR SPECIFICALLY INHIBITING HISTONE DEACETYLASE-7 AND 8 | METHYLGENE, INC. (CA) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072770-A1 | Methods for specifically inhibiting histone deacetylase-7 and 8 | HDAC8, HDAC7, HDAC1 | HDAC1 3/4885DYRK1A 3967/4885CLK4 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.