Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 10/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 4/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539401 | 0.80 | NISCH (0.66) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL5307832 | 0.79 | TOP2A (0.61) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL6746742 | 0.79 | NISCH (0.80) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL5441899 | 0.78 | NISCH (0.59) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL8537356 | 0.76 | NISCH (0.59) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL4298620 | 0.72 | NISCH (0.58) | NISCHGAATSHRTOP2ATOP2B | |
| Formic Acid SCHEMBL4823088 | 0.71 | NISCH (0.67) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL6751839 | 0.71 | TOP2A (0.66) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL8536718 | 0.71 | NISCH (0.64) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL11273702 | 0.69 | NISCH (0.58) | NISCHGAATSHRTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1130019-B1 | 2,4-bis((4-Amidino)phenyl)furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-0941991-B1 | 2,4-Bis (4-amidino)phenyl furans as anti-pneumocystis carinii agents | UNIV NORTH CAROLINA (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1130019-A1 | 2,4-bis((4-Amidino)phenyl)furans as anti-pneumocystis carinii agents | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-09-05 | — | — | EP | disclosed |
| US-6127554-A | MAKING 2,4-BIS(HALO-PHENYL)FURAN COMPOUNDS BY REACTING 2,4-BIS(HALO-PHENYL),5-((HALO-PHENYL)CARBONYL)FURAN IN THE PRESENCE OF A BASE; CHEMICAL INTERMEDIATE TO SYNTHESIS OF ANTIMICROBIAL AGENT | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-10-03 | — | — | US | disclosed |
| US-6008247-A | TREATING PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-28 | — | — | US | disclosed |