SCHEMBL6756004

SCHEMBL6756004

Cc1cccc2c1CC/C2=C/C(N)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.51
RXRA P19793 2/20 0.51
MAOB P27338 2/20 0.48
MAOA P21397 1/20 0.48
LOX P28300 1/20 0.48
CYP19A1 P11511 2/20 0.47
CYP11B1 P15538 1/20 0.47
CYP11B2 P19099 1/20 0.47
PARP1 P09874 1/20 0.41
PARP10 Q53GL7 1/20 0.41
PARP11 Q9NR21 1/20 0.41
TYMS P04818 1/20 0.39
MYC P01106 1/20 0.37
NOTUM Q6P988 1/20 0.36
ACHE P22303 1/20 0.36
TYR P14679 1/20 0.35
ALDH1A1 P00352 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
CA1 P00915 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6756006 1.00 LMNA (0.51) LMNARXRAMAOBMAOALOX
SCHEMBL6756002 1.00 LMNA (0.51) LMNARXRAMAOBMAOALOX
SCHEMBL6785050 0.85 RXRA (0.55) LMNARXRAMAOBCYP19A1CYP11B1
SCHEMBL6785053 0.85 RXRA (0.55) LMNARXRAMAOBCYP19A1CYP11B1
SCHEMBL6785056 0.85 RXRA (0.55) LMNARXRAMAOBCYP19A1CYP11B1
SCHEMBL9390068 0.84 RXRA (0.48) LMNARXRAMAOBMAOALOX
SCHEMBL6785652 0.84 RXRA (0.48) LMNARXRAMAOBMAOALOX
SCHEMBL6785655 0.84 RXRA (0.48) LMNARXRAMAOBMAOALOX
Hydrochloric Acid SCHEMBL6785658 0.84 RXRA (0.54) LMNARXRAMAOBCYP19A1CYP11B1
SCHEMBL7564439 0.81 MAOB (0.63) LMNARXRAMAOBMAOALOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0759025-B1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE WELLCOME FOUND (GB) 1999-07-21 EP claimed
EP-0759025-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1997-02-26 EP claimed
WO-1995030644-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-16 WO claimed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO claimed
US-20040116405-A1 Use of bicyclic esters or amides for the treatment of diseases responsive to enhanced potassium channel activity GLAXO GROUP LIMITED (GB) 2004-06-17 US disclosed
EP-1358150-A1 USE OF BICYCLIC ESTERS OR AMIDES FOR THE TREATMENT OF DISEASES RESPONSIVE TO ENHANCED POTASSIUM CHANNEL ACTIVITY GLAXO GROUP LIMITED (GB) 2003-11-05 EP disclosed
WO-2002062745-A1 USE OF BICYCLIC ESTERS OR AMIDES FOR THE TREATMENT OF DISEASES RESPONSIVE TO ENHANCED POTASSIUM CHANNEL ACTIVITY GLAXO GROUP LIMITED (GB) 2002-08-15 WO disclosed
EP-0759025-B1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE WELLCOME FOUND (GB) 1999-07-21 EP disclosed
US-5719186-A CENTRAL MUSCLE RELAXANTS, ANXIOLYTIC AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTICONVULSANTS GLAXO WELLCOME INC. (US) 1998-02-17 US disclosed
EP-0759025-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1997-02-26 EP disclosed
WO-1995030644-A1 AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE THE WELLCOME FOUNDATION LIMITED (GB) 1995-11-16 WO disclosed