SCHEMBL6756862

SCHEMBL6756862

O=C(Nc1ccc(Cl)cc1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC10A6 Q3KNW5 2/20 1.00
SLC10A2 Q12908 1/20 1.00
SLC10A1 Q14973 1/20 1.00
METAP2 P50579 3/20 0.73
KMT2A Q03164 2/20 0.58
KDM4E B2RXH2 1/20 0.58
MEN1 O00255 1/20 0.58
GPR27 Q9NS67 10/20 0.58
AVPR2 P30518 2/20 0.57
NPC1 O15118 1/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.55
GAA P10253 1/20 0.55
RAB9A P51151 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
CCR9 P51686 1/20 0.54
FLT1 P17948 2/20 0.53
FLT4 P35916 2/20 0.53
KDR P35968 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7126120 0.99 SLC10A6 (0.98) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL5115455 0.94 SLC10A6 (0.88) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL6861824 0.93 SLC10A6 (0.87) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL7116008 0.92 SLC10A6 (0.85) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL7118571 0.92 SLC10A6 (0.85) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL5597977 0.91 SLC10A6 (0.83) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL6754585 0.90 SLC10A6 (0.81) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL7208184 0.86 SLC10A6 (0.76) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL30777866 0.86 SLC10A6 (0.75) SLC10A6SLC10A2SLC10A1METAP2KMT2A
SCHEMBL27089455 0.86 SLC10A6 (0.75) SLC10A6SLC10A2SLC10A1METAP2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040167180-A1 Methods for anti-tumor therapy COMPASS PHARMACEUTICALS, LLC 2004-08-26 US claimed
US-6716879-B2 ADMINISTERING AN EFFECTIVE AMOUNT OF SULFONYLAMINO-SUBSTITUTED N-ARYL- OR HETEROACRYL OR ALKYL OR CYCLOALKYLCARBOXAMIDE DERIVATIVES OR SALTS, ESTERS, AMIDES OR PRODRUG TO TREAT TUMOR COMPASS PHARMACEUTICALS, LLC 2004-04-06 US claimed
EP-1317260-A2 METHODS FOR TREATING TUMORS USING SULFONYL COMPOUNDS Signature Bioscience, Inc. (US) 2003-06-11 EP claimed
US-20020082243-A1 Methods for anti-tumor therapy PHOENIX ONCOLOGY, LLC 2002-06-27 US claimed
WO-2002017897-A2 METHODS FOR TREATING TUMORS USING SULFONYL COMPOUNDS PRIMECYTE, INC. (US) 2002-03-07 WO claimed
EP-1317260-A2 METHODS FOR TREATING TUMORS USING SULFONYL COMPOUNDS Signature Bioscience, Inc. (US) 2003-06-11 EP disclosed
WO-2002017897-A2 METHODS FOR TREATING TUMORS USING SULFONYL COMPOUNDS PRIMECYTE, INC. (US) 2002-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020082243-A1 Methods for anti-tumor therapy HCCS, PAICS, TP53 SLC10A6 1719/4885SLC10A2 846/4885SLC10A1 941/4885
US-20040167180-A1 Methods for anti-tumor therapy HCCS, PAICS, TP53 SLC10A6 1719/4885SLC10A2 846/4885SLC10A1 941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.