SCHEMBL6757192

SCHEMBL6757192

Cc1ccc2nc(C(C)C)[nH]c2c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.42
HSD17B10 Q99714 2/20 0.42
LMNA P02545 1/20 0.42
CYP1A2 P05177 1/20 0.37
ADORA3 P0DMS8 2/20 0.36
ADORA2A P29274 2/20 0.36
ADORA1 P30542 2/20 0.36
ADORA2B P29275 1/20 0.36
ALDH1A1 P00352 3/20 0.34
PDE3B Q13370 3/20 0.34
PDE3A Q14432 3/20 0.34
HPGD P15428 2/20 0.34
USP2 O75604 1/20 0.34
HTT P42858 1/20 0.34
PDE2A O00408 1/20 0.34
P2RY12 Q9H244 1/20 0.34
MAPT P10636 1/20 0.33
MAPK1 P28482 1/20 0.33
SCN10A Q9Y5Y9 1/20 0.33
GSK3B P49841 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6515025 0.86 CYP1A2 (0.53) KDM4EHSD17B10CYP1A2ALDH1A1PDE3B
SCHEMBL15042816 0.84 KDM4E (0.50) KDM4EHSD17B10LMNACYP1A2ADORA3
SCHEMBL24312996 0.84 KDM4E (0.41) KDM4EHSD17B10LMNACYP1A2ADORA3
SCHEMBL6753935 0.83 SCN10A (0.38) KDM4EHSD17B10CYP1A2ALDH1A1PDE3B
SCHEMBL13542739 0.82 KDM4E (0.40) KDM4EHSD17B10LMNACYP1A2ADORA3
SCHEMBL22962142 0.82 KDM4E (0.40) KDM4EHSD17B10LMNACYP1A2ADORA3
SCHEMBL5201662 0.78 KDM4E (0.46) KDM4EHSD17B10LMNAADORA3ADORA2A
SCHEMBL353027 0.76 ALDH1A1 (0.41) KDM4EHSD17B10LMNAADORA3ALDH1A1
SCHEMBL12328110 0.75 TYMS (0.43) KDM4EHSD17B10LMNACYP1A2ADORA3
SCHEMBL12328106 0.75 HSD17B10 (0.44) KDM4EHSD17B10LMNACYP1A2ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0428260-B1 Metal surface treatment agents SANWA LAB LTD (JP) 2000-01-05 EP claimed
EP-0562187-B1 Process for production of copper through-hole printed wiring boards SANWA LAB LTD (JP) 1996-01-10 EP claimed
US-5275694-A Printed circuits with copper through holes, negative patterns, photoresists, lamination, dipping and etching SANWA LABORATORY LTD. (JP) 1994-01-04 US claimed
EP-0562187-A1 Process for production of copper through-hole printed wiring boards SANWA LABORATORY LTD. (JP) 1993-09-29 EP claimed
EP-0428260-A2 Metal surface treatment agents SANWA LABORATORY LTD. (JP) 1991-05-22 EP claimed
US-8183276-B2 Therapeutic agents MERCK SHARP & DOHME CORP. 2012-05-22 US disclosed
US-20100324029-A1 THERAPEUTIC AGENTS MERCK SHARP & DOHME CORP. 2010-12-23 US disclosed
US-7652023-B2 Heterocyclic CETP inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2010-01-26 US disclosed
US-20070135467-A1 HETEROCYCLIC CETP INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2007-06-14 US disclosed
US-6712262-B2 BENZIMIDAZOLE AND IODINE COMPOUNDS TAMURAKAKEN CORPORATION (JP) 2004-03-30 US disclosed
US-20030141351-A1 Water-soluble preflux, printed circuit board, and process for treating the surface of a metal in a printed circuit board TAMURA CORPORATION (JP) 2003-07-31 US disclosed
EP-0428260-B1 Metal surface treatment agents SANWA LAB LTD (JP) 2000-01-05 EP disclosed
EP-0562187-B1 Process for production of copper through-hole printed wiring boards SANWA LAB LTD (JP) 1996-01-10 EP disclosed
US-5275694-A Printed circuits with copper through holes, negative patterns, photoresists, lamination, dipping and etching SANWA LABORATORY LTD. (JP) 1994-01-04 US disclosed
EP-0562187-A1 Process for production of copper through-hole printed wiring boards SANWA LABORATORY LTD. (JP) 1993-09-29 EP disclosed
EP-0428260-A2 Metal surface treatment agents SANWA LABORATORY LTD. (JP) 1991-05-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070135467-A1 HETEROCYCLIC CETP INHIBITORS CETP, CES1, NPC1 KDM4E 1618/4885HSD17B10 255/4885LMNA 170/4885
US-20100324029-A1 THERAPEUTIC AGENTS PSEN2, PSEN1, BACE2 KDM4E 3970/4885HSD17B10 1886/4885LMNA 1357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.