Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6757634 | 0.92 | TGFBR1 (0.67) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6760985 | 0.82 | TGFBR1 (0.70) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL29358831 | 0.81 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL29378125 | 0.81 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL373422 | 0.81 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| Hydrochloric Acid SCHEMBL140197 | 0.80 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| Hydrochloric Acid SCHEMBL29541686 | 0.80 | TGFBR1 (1.00) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| Water SCHEMBL21459280 | 0.80 | TGFBR1 (0.98) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| Hydrochloric Acid SCHEMBL14778775 | 0.79 | TGFBR1 (0.98) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| Hydrochloric Acid SCHEMBL29361019 | 0.79 | TGFBR1 (0.98) | TGFBR1MAPK14RIPK2ACVR1BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220230-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. | 2004-11-04 | — | — | US | claimed |
| US-20040220230-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. | 2004-11-04 | — | — | US | disclosed |
| US-20030166633-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166633-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | TGFBR1 431/4885MAPK14 3277/4885RIPK2 2601/4885 |
| US-20040220230-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | TGFBR1 485/4885MAPK14 3471/4885RIPK2 3143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.