Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KIF20A | O95235 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758571 | 1.00 | MAPT (0.44) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL6758597 | 0.87 | NEK2 (0.50) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL6758589 | 0.87 | NEK2 (0.50) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL8325698 | 0.81 | APP (0.59) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6755674 | 0.80 | CHEK1 (0.58) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL6755673 | 0.80 | CHEK1 (0.58) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL8322010 | 0.76 | KMT2A (0.54) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8322008 | 0.76 | KMT2A (0.54) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6754816 | 0.74 | KIF20A (0.46) | MAPTKDM4EGAAALDH1A1MEN1 | |
| SCHEMBL6755586 | 0.74 | KIF20A (0.46) | MAPTKDM4EGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3507497-B2 | — | — | 2004-03-15 | — | — | JP | claimed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | claimed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | claimed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | claimed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | disclosed |
| US-5397787-A | Tyrosine kinase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-03-14 | — | — | US | disclosed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | disclosed |