Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 5/20 | 0.44 |
| ▸ | KIF20A | O95235 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758573 | 0.81 | MAPT (0.44) | APPMAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL6758571 | 0.81 | MAPT (0.44) | APPMAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL6758597 | 0.81 | NEK2 (0.50) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6758589 | 0.81 | NEK2 (0.50) | MAPTKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8322010 | 0.78 | KMT2A (0.54) | MAPTKDM4ECYP1A2CYP2C19CYP2D6 | |
| SCHEMBL8322008 | 0.78 | KMT2A (0.54) | MAPTKDM4ECYP1A2CYP2C19CYP2D6 | |
| SCHEMBL6758581 | 0.76 | CHEK1 (0.66) | APPMAPTKIF20AKMT2AALDH1A1 | |
| SCHEMBL4328855 | 0.74 | APP (1.00) | APPMAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL29956273 | 0.74 | KMT2A (0.54) | KDM4ECYP1A2CYP2C19KMT2AMEN1 | |
| SCHEMBL2265113 | 0.74 | KMT2A (0.54) | KDM4ECYP1A2CYP2C19KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | claimed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | disclosed |
| US-5397787-A | Tyrosine kinase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-03-14 | — | — | US | disclosed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | disclosed |