Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.66 |
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | KIF20A | O95235 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 3/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13100670 | 0.85 | CHEK1 (0.63) | CHEK1APPKMT2ALRRK2KIF20A | |
| SCHEMBL13100345 | 0.83 | CHEK1 (0.60) | CHEK1APPKMT2ALRRK2KIF20A | |
| SCHEMBL29194854 | 0.82 | CHEK1 (0.59) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL30845335 | 0.82 | CHEK1 (0.59) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL6753356 | 0.81 | NEK2 (0.68) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL6755673 | 0.81 | CHEK1 (0.58) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL6753353 | 0.81 | NEK2 (0.68) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL6755674 | 0.81 | CHEK1 (0.58) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL7842449 | 0.80 | CHEK1 (1.00) | CHEK1KMT2ALRRK2KIF20ACLK1 | |
| SCHEMBL7841437 | 0.80 | CHEK1 (1.00) | CHEK1KMT2ALRRK2KIF20ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737518-B1 | REACTING 4,5-EPOXYMORPHINAN-6-OLS WITH BROMOGLUCURONIDES IN THE PRESENCE OF ZINC BROMIDE; DEPROTECTING END PRODUCTS TO MAKE MORPHINE-6-BETA-D-GLUCURONIDE (M6G) | CENES LIMITED (GB) | 2004-05-18 | — | — | US | claimed |
| US-20040053854-A1 | Process for preparation of 4,5-Epoxymorphinan-6-oxyglucuronides | CENES LIMITED (GB) | 2004-03-18 | — | — | US | claimed |
| JP-3507497-B2 | — | — | 2004-03-15 | — | — | JP | claimed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | claimed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | claimed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | claimed |
| US-6737518-B1 | REACTING 4,5-EPOXYMORPHINAN-6-OLS WITH BROMOGLUCURONIDES IN THE PRESENCE OF ZINC BROMIDE; DEPROTECTING END PRODUCTS TO MAKE MORPHINE-6-BETA-D-GLUCURONIDE (M6G) | CENES LIMITED (GB) | 2004-05-18 | — | — | US | disclosed |
| US-20040053854-A1 | Process for preparation of 4,5-Epoxymorphinan-6-oxyglucuronides | CENES LIMITED (GB) | 2004-03-18 | — | — | US | disclosed |
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | disclosed |
| US-5397787-A | Tyrosine kinase inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-03-14 | — | — | US | disclosed |
| EP-0626963-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014808-A1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA SRL (IT) | 1994-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053854-A1 | Process for preparation of 4,5-Epoxymorphinan-6-oxyglucuronides | OGFR, OSTC, GALE | CHEK1 4880/4885APP 4722/4885KMT2A 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.