Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 1.00 |
| ▸ | KIF20A | O95235 | 3/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.65 |
| ▸ | CLK1 | P49759 | 5/20 | 0.65 |
| ▸ | CLK2 | P49760 | 2/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841437 | 1.00 | CHEK1 (1.00) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL2725998 | 0.85 | KIF20A (1.00) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL2726003 | 0.85 | KIF20A (1.00) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL6758581 | 0.80 | CHEK1 (0.66) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL14956952 | 0.79 | DYRK1A (1.00) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL13035549 | 0.79 | DYRK1A (1.00) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL13100670 | 0.78 | CHEK1 (0.63) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL5258187 | 0.78 | CHEK1 (0.63) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL5258189 | 0.78 | CHEK1 (0.63) | CHEK1KIF20ADYRK1ACLK1CLK2 | |
| SCHEMBL5258995 | 0.77 | CHEK1 (0.62) | CHEK1KIF20ADYRK1ACLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835244-B1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PROD (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0835244-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-15 | — | — | EP | claimed |
| WO-1996039387-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | claimed |
| EP-0835244-B1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PROD (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0835244-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| WO-1996039387-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |