Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | RYR2 | Q92736 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | VHL | P40337 | 1/20 | 0.46 |
| ▸ | ELOC | Q15369 | 1/20 | 0.46 |
| ▸ | ELOB | Q15370 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366190 | 0.90 | KDM4E (0.82) | KDM4EHTTALDH1A1RYR2MAOA | |
| SCHEMBL11283 | 0.87 | KDM4E (0.77) | KDM4EHTTALDH1A1RYR2MAOA | |
| SCHEMBL29596397 | 0.87 | KDM4E (0.77) | KDM4EHTTALDH1A1RYR2MAOA | |
| SCHEMBL68574 | 0.83 | KDM4E (0.71) | KDM4EHTTALDH1A1RYR2MAOA | |
| SCHEMBL22714471 | 0.81 | KDM4E (0.68) | KDM4EHTTALDH1A1MAOAMAOB | |
| SCHEMBL11477365 | 0.80 | KDM4E (0.67) | KDM4EHTTALDH1A1MAOAMAOB | |
| SCHEMBL29756838 | 0.78 | KDM4E (0.63) | KDM4EHTTALDH1A1VHLELOC | |
| SCHEMBL20165128 | 0.78 | KDM4E (0.63) | KDM4EHTTALDH1A1VHLELOC | |
| SCHEMBL7222447 | 0.78 | KDM4E (0.63) | KDM4EHTTALDH1A1RYR2MAOA | |
| SCHEMBL2775772 | 0.77 | KDM4E (0.63) | KDM4EHTTALDH1A1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115836077-B | Oxazaspiro derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2025-05-13 | — | — | CN | disclosed |
| US-20250129076-A1 | FUSED TETRACYCLIC COMPOUNDS, COMPOSITIONS AND DIAGNOSTIC APPLICATIONS THEREOF | BENAZIR FATHIMA (IN) | 2025-04-24 | — | — | US | disclosed |
| US-12037501-B2 | Photocurable ink composition and image recording method | FUJIFILM CORPORATION (JP) | 2024-07-16 | — | — | US | disclosed |
| US-11850287-B2 | Heterocyclic acyl hydrazone linkers, methods and uses thereof | ONTARIO INSTITUTE FOR CANCER SEARCH (OICR) (CA) | 2023-12-26 | — | — | US | disclosed |
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| CN-113754685-B | Dihydrothiochromene pyrazole derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| EP-4190789-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-06-07 | — | — | EP | disclosed |
| EP-4190789-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-06-07 | — | — | EP | disclosed |
| US-5547975-A | ANTIARTHRIC AGENTS, ANALGESICS AND ANTIPYRETICS; INHIBITORS OF CYCLOOXYGENASE II; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 1996-08-20 | — | — | US | disclosed |
| WO-1996009304-A1 | BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |
| EP-0396620-B1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-11 | — | — | EP | disclosed |
| US-5185364-A | Selectively inhibit alpha-2-adrenergic receptors | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
| US-5140039-A | Antidepressants, metabolic disorders | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5089519-A | Antidepressants; antagonists for alpha-2-adrenergic receptors | ABBOTT LABORATORIES (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0396620-A4 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | — | 1991-01-23 | — | — | EP | disclosed |
| EP-0396620-A1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS. | ABBOTT LAB (US) | 1990-11-14 | — | — | EP | disclosed |
| EP-0325964-A1 | Aminomethyl-chroman and -thiochroman compounds | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |
| WO-1989006534-A1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234962-A1 | OXA-AZASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | PIK3CD, PIK3CA, PIK3R5 | KDM4E 3238/4885HTT 4290/4885ALDH1A1 704/4885 |
| US-20250129076-A1 | FUSED TETRACYCLIC COMPOUNDS, COMPOSITIONS AND DIAGNOSTIC APPLICATIONS THEREOF | POLRMT, POLM, DNTT | KDM4E 4802/4885HTT 644/4885ALDH1A1 1893/4885 |
| US-11850287-B2 | Heterocyclic acyl hydrazone linkers, methods and uses thereof | HDAC6, C9, AADAC | KDM4E 1071/4885HTT 1365/4885ALDH1A1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.