Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328410 | 0.91 | ACE (0.73) | ACE | |
| Imidapril SCHEMBL11014327 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL3193644 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL7354516 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL34099 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL12894585 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL34098 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL6516062 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL22492310 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL683273 | 0.87 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274230-B1 | USE OF 2-OXO-IMIDAZOLIDINE DERIVATIVES IN THE PROPHYLAXIS AND TREATMENT OF HEART FAILURE | TANABE SEIYAKU CO., LTD. (JP) | 1992-10-14 | — | — | EP | claimed |
| EP-1442743-A1 | Medicament comprising alpha-lipoic acid, ambroxol and/or inhibitors of the angiotensin converting enzyme (ACE) for use in the treatment of neurodegenerative diseases | KeyNeurotek AG (DE) | 2004-08-04 | — | — | EP | disclosed |