Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.54 |
| ▸ | S100A10 | P60903 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447749 | 0.87 | HPGD (0.66) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| SCHEMBL6778027 | 0.87 | HPGD (0.70) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| SCHEMBL2406839 | 0.87 | CYP1A2 (0.76) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| SCHEMBL31383422 | 0.87 | CYP1A2 (0.76) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| Hydrochloric Acid SCHEMBL7134403 | 0.86 | HPGD (0.63) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| SCHEMBL10620724 | 0.85 | ALDH1A1 (0.56) | HPGDCYP2C9CYP1A2HSD17B10ANXA2 | |
| SCHEMBL14471210 | 0.84 | HPGD (0.61) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| SCHEMBL19940906 | 0.84 | CYP3A4 (0.54) | HPGDCYP2C9CYP1A2HSD17B10ANXA2 | |
| SCHEMBL1000649 | 0.83 | HPGD (0.59) | HPGDCYP2C9CYP1A2HSD17B10APEX1 | |
| SCHEMBL900829 | 0.81 | TSHR (0.61) | HPGDCYP2C9ANXA2S100A10APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119548-B1 | 3-(3-CHLORO-4-HYDROXYPHENYLAMINO)-4-(2-NITROPHENYL)-1H-PYRROLE-2,5-DIONE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITOR (GSK-3) | SMITHKLINE BEECHAM PLC (GB) | 2004-12-08 | — | — | EP | disclosed |
| US-6719520-B2 | FOR INHIBITION OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3); TREATMENT AND PROPHYLAXIS FOR DIABETES, CHRONIC NEURODEGENERATIVE CONDITIONS, MOOD DISORDERS SUCH AS SCHIZOPHRENIA AND MANIC DEPRESSION AND HAIR LOSS AND CANCER | SMITHKLINE BEECHAM CORPORATION | 2004-04-13 | — | — | US | disclosed |
| US-20040010031-A1 | Novel method and compounds | SMITHKLINE BEECHAM P.L.C. | 2004-01-15 | — | — | US | disclosed |
| WO-2001074771-A1 | PYRROLE-2,5-DIONE DERIVATIVES FOR THE TREATMENT OF DIABETES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-10-11 | — | — | WO | disclosed |
| EP-1119548-A1 | PYRROLE-2,5-DIONES AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021927-A2 | PYRROLE-2,5-DIONES AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010031-A1 | Novel method and compounds | GSK3A, GSK3B, GSKIP | HPGD 1640/4885CYP2C9 2114/4885CYP1A2 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.