Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.50 |
| ▸ | CDC25A | P30304 | 9/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5712077 | 0.84 | ALDH1A1 (0.53) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL9373300 | 0.80 | KDM4E (0.39) | ALDH1A1MAPTGAAKDM4EGRM5 | |
| SCHEMBL9370111 | 0.78 | ALDH1A1 (0.40) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL9370114 | 0.78 | ALDH1A1 (0.40) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL19949917 | 0.78 | KDM4E (0.51) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6698921 | 0.78 | ALDH1A1 (0.70) | ALDH1A1NPC1RAB9AMEN1MAPT | |
| SCHEMBL29531557 | 0.78 | ALDH1A1 (0.70) | ALDH1A1NPC1RAB9AMEN1MAPT | |
| SCHEMBL25229724 | 0.76 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AMEN1MAPT | |
| SCHEMBL9549231 | 0.76 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AMEN1MAPT | |
| SCHEMBL15921493 | 0.76 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5077410-A | Hypotensive agents, antiedemic agents and diuretics | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-31 | — | — | US | claimed |
| EP-0243982-B1 | 1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINONE-4-OXIME DERIVATIVE, PROCESS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND INTERMEDIATES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-17 | — | — | EP | claimed |
| WO-1987006580-A1 | 1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINONE-4-OXIME DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-05 | — | — | WO | claimed |
| EP-0243982-A1 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivative, process for the production thereof, pharmaceutical composition and intermediates | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-04 | — | — | EP | claimed |
| US-20040024209-A1 | 1-Aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents | SCHNUTE MARK E (US) | 2004-02-05 | — | — | US | disclosed |
| US-6653307-B2 | Such as N-(4-chlorobenzyl)-6-(4-morpholinylmethyl)-4-oxo-1-phenyl-1,4-dihydro-3-quinolinecarboxamide for treatment of herpes virus; viral DNA polymerase inhibitors | PHARMACIA & UPJOHN COMPANY | 2003-11-25 | — | — | US | disclosed |
| CN-1432001-A | 1-aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents | UPJOHN CO (US) | 2003-07-23 | — | — | CN | disclosed |
| US-20020103220-A1 | 1-Aryl-4oxo-1,4-Dihydro-3-quinolinecarboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-08-01 | — | — | US | disclosed |
| EP-0315115-B1 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof | MOCHIDA PHARM CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| US-5077410-A | Hypotensive agents, antiedemic agents and diuretics | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-31 | — | — | US | disclosed |
| EP-0243982-B1 | 1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINONE-4-OXIME DERIVATIVE, PROCESS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND INTERMEDIATES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-17 | — | — | EP | disclosed |
| US-4968680-A | HYPOTENSIVE, ANTIEDEMIC, DIURETIC | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1990-11-06 | — | — | US | disclosed |
| US-4839368-A | DIURETICS, HYPOTENSIVE AGENTS, ANTIEDEMIC AGENTS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0315115-A2 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, process for producing them and use thereof | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4816454-A | CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-03-28 | — | — | US | disclosed |
| WO-1987006580-A1 | 1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINONE-4-OXIME DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-05 | — | — | WO | disclosed |
| EP-0243982-A1 | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivative, process for the production thereof, pharmaceutical composition and intermediates | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-04 | — | — | EP | disclosed |
| EP-0175363-A2 | 4,5-Dihydro-3(2H)-pyridazinones, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024209-A1 | 1-Aryl-4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, IRF3 | ALDH1A1 668/4885ALDH2 2830/4885ALDH3A1 985/4885 |
| US-20020103220-A1 | 1-Aryl-4oxo-1,4-Dihydro-3-quinolinecarboxamides as antiviral agents | ZC3HAV1, IRF3, ZC3HAV1L | ALDH1A1 463/4885ALDH2 2348/4885ALDH3A1 676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.