Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6760976 | 0.86 | TGFBR1 (0.54) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL6760970 | 0.85 | TGFBR1 (0.69) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL6761614 | 0.84 | TGFBR1 (0.61) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL7250793 | 0.82 | TGFBR1 (0.74) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL5199866 | 0.80 | TGFBR1 (0.48) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL6760994 | 0.80 | TGFBR1 (0.45) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL5198642 | 0.79 | KDM4E (0.49) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL5201273 | 0.78 | TGFBR1 (0.47) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL5199441 | 0.78 | TGFBR1 (0.47) | TGFBR1MTORMAPK14RIPK2ACVR1B | |
| SCHEMBL5497047 | 0.78 | TGFBR1 (0.54) | TGFBR1MTORMAPK14RIPK2ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220230-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. | 2004-11-04 | — | — | US | disclosed |
| US-20030166633-A1 | Pyridinylimidazoles | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166633-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | TGFBR1 431/4885MTOR 3903/4885MAPK14 3277/4885 |
| US-20040220230-A1 | Pyridinylimidazoles | NR0B1, NR1I2, NR0B2 | TGFBR1 485/4885MTOR 4099/4885MAPK14 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.