Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7822476 | 0.82 | TSHR (0.40) | TSHRMAOBKMT2ALMNAMAOA | |
| SCHEMBL6766166 | 0.82 | CYP2D6 (0.40) | MAOBKMT2ALMNAMAOACYP2D6 | |
| SCHEMBL5780097 | 0.80 | KMT2A (0.37) | TSHRMAOBKMT2AMAOACYP2D6 | |
| SCHEMBL6768350 | 0.77 | KMT2A (0.47) | TSHRMAOBKMT2AMAOAALDH1A1 | |
| SCHEMBL5779088 | 0.76 | KMT2A (0.40) | MAOBKMT2AMAOAALDH1A1 | |
| SCHEMBL6767999 | 0.76 | ALDH1A1 (0.44) | KMT2ALMNAALDH1A1 | |
| SCHEMBL7821687 | 0.74 | MAOB (0.40) | TSHRMAOBKMT2AMAOAPDCD1 | |
| SCHEMBL5782379 | 0.73 | KMT2A (0.37) | MAOBKMT2AMAOAPDCD1CD274 | |
| SCHEMBL10633559 | 0.72 | APP (0.52) | TSHRMAOBKMT2AGRM5ALDH1A1 | |
| SCHEMBL6767953 | 0.72 | HTR7 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |