Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368170 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL28139048 | 0.79 | CAPN1 (0.44) | CAPN1ALDH1A1KMT2ASIRT2MAPT | |
| Hydrochloric Acid SCHEMBL3263820 | 0.79 | — | — | |
| SCHEMBL28303337 | 0.79 | — | — | |
| SCHEMBL9528563 | 0.75 | ALDH1A1 (0.43) | CAPN1ALDH1A1KMT2ASIRT2MAPT | |
| SCHEMBL2889586 | 0.73 | — | — | |
| SCHEMBL153032 | 0.73 | — | — | |
| Methylamine SCHEMBL27486107 | 0.73 | ALDH1A1 (0.47) | CAPN1ALDH1A1KMT2ATSHR | |
| SCHEMBL9584944 | 0.72 | SIRT2 (0.35) | CAPN1ALDH1A1KMT2ASIRT2MAPT | |
| SCHEMBL5158782 | 0.72 | CAPN1 (0.47) | CAPN1ALDH1A1KMT2ASIRT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730694-B1 | SPLA2 IS A RATE LIMITING ENZYME IN THE ARACHIDONIC ACID CASCADE WHICH HYDROLYZES MEMBRANE PHOSPHOLIPIDS; TREATMENT OF SEPSIS OR RHEUMATOID ARTHRITIS | ELI LILLY AND COMPANY | 2004-05-04 | — | — | US | disclosed |
| EP-1307461-A2 | SUBSTITUTED PYRROLE COMPOUNDS AND THEIR USE AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012249-A2 | SUBSTITUTED PYRROLE COMPOUNDS AND THEIR USE AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-02-14 | — | — | WO | disclosed |