Chamaecin

Chamaecin

SCHEMBL676459

CC(C)c1ccc(C=O)c(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 5/20 1.00
TRPA1 O75762 1/20 0.53
PTGS1 P23219 1/20 0.53
CACNA1C Q13936 1/20 0.53
TRIM24 O15164 2/20 0.52
TRIM33 Q9UPN9 2/20 0.52
RNASEH1 O60930 1/20 0.48
ALDH1A1 P00352 2/20 0.47
ALOX12 P18054 2/20 0.47
HTT P42858 2/20 0.47
GAA P10253 1/20 0.47
HIF1A Q16665 1/20 0.47
ERN1 O75460 3/20 0.46
PTPN1 P18031 1/20 0.45
KDM4E B2RXH2 1/20 0.44
MDM4 O15151 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
TP53 P04637 1/20 0.44
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4160329 0.87 TYR (0.77) TYRTRPA1PTGS1CACNA1CTRIM24
SCHEMBL14354175 0.86 TYR (0.76) TYRTRPA1PTGS1CACNA1CTRIM24
SCHEMBL1527156 0.84 TYR (0.72) TYRTRPA1PTGS1CACNA1CTRIM24
SCHEMBL17399576 0.82 TYR (0.69) TYRTRPA1PTGS1CACNA1CTRIM24
SCHEMBL1527109 0.82 TYR (0.69) TYRTRIM24TRIM33ALDH1A1HTT
SCHEMBL11585654 0.82 TYR (0.69) TYRPTGS1TRIM24TRIM33CYP3A4
SCHEMBL5811015 0.82 TYR (0.69) TYRTRPA1PTGS1CACNA1CTRIM24
Chamaecin SCHEMBL7091917 0.81 TYR (0.66) TYRTRPA1PTGS1CACNA1CTRIM24
SCHEMBL24581328 0.81 TYR (0.68) TYRTRPA1PTGS1CACNA1CTRIM24
Salicyladehyde SCHEMBL7094765 0.80 TYR (0.67) TYRTRPA1PTGS1CACNA1CTRIM24

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4587669-B2 2010-11-24 JP claimed
CN-1228356-C Norbornene polymerization catalyst system and its preparing process CHINESE ACAD INST CHEMISTRY (CN) 2005-11-23 CN claimed
CN-1200017-C Nickel compound catalyst system for polymerization of norbornene and its prepn CHINESE ACAD INST CHEMISTRY (CN) 2005-05-04 CN claimed
JP-2005509662-A 2005-04-14 JP claimed
CN-1589136-A Pharmaceutical and cosmetic compositions containing aromatic aldehydes bearing oxygen-containing groups CUTANIX CORP (US) 2005-03-02 CN claimed
CN-1167720-C Polymeric catalyst system of norbornaene and its preparing process 中国科学院化学研究所 2004-09-22 CN claimed
EP-1443915-A1 PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING OXY GROUP-BEARING AROMATIC ALDEHYDES Cutanix Corporation (US) 2004-08-11 EP claimed
CN-1139606-C Norbornene catalytic system and its preparation method and application 中国科学院化学研究所 2004-02-25 CN claimed
US-20030157154-A1 Compositions containing hydroxy aromatic aldehydes and their use in treatments CUTANIX CORPORATION 2003-08-21 US claimed
WO-2003043621-A1 PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING OXY GROUP-BEARING AROMATIC ALDEHYDES CUTANIX CORPORATION (US) 2003-05-30 WO claimed
CN-1394685-A Norbornene catalytic system and its preparation method and application CHINESE ACAD INST CHEMISTRY (CN) 2003-02-05 CN claimed
CN-1390867-A Polymeric catalyst system of norbornaene and its preparing process CHINESE ACAD INST CHEMISTRY (CN) 2003-01-15 CN claimed
CN-1388140-A Nickel compound catalyst system for polymerization of norbornene and its prepn CHINESE ACAD INST CHEMISTRY (CN) 2003-01-01 CN claimed
CN-1388139-A Norbornene polymerization catalyst system and its preparing process CHINESE ACAD INST CHEMISTRY (CN) 2003-01-01 CN claimed
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2026-04-02 US disclosed
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 US disclosed
EP-4229045-B1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER BROAD INST INC (US) 2025-11-12 EP disclosed
CN-1388140-A Nickel compound catalyst system for polymerization of norbornene and its prepn CHINESE ACAD INST CHEMISTRY (CN) 2003-01-01 CN disclosed
CN-1388139-A Norbornene polymerization catalyst system and its preparing process CHINESE ACAD INST CHEMISTRY (CN) 2003-01-01 CN disclosed
WO-2002032908-A2 NON-METALLOCENE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND USE OF THE SAME FOR THE POLYMERISATION OF OLEFINS BASELL POLYOLEFINE GMBH (DE) 2002-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030157154-A1 Compositions containing hydroxy aromatic aldehydes and their use in treatments TYR, HRH1, HRH2 TYR 1/4885TRPA1 67/4885PTGS1 411/4885
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS TFPI, F3, BTK TYR 44/4885TRPA1 489/4885PTGS1 2837/4885
US-12558341-B2 Oral complement factor D inhibitors CFD, CFH, CFB TYR 712/4885TRPA1 3025/4885PTGS1 1252/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.