Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222578 | 0.80 | TYMS (0.50) | TYMSPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL17829223 | 0.78 | KDM4E (0.64) | TYMSPOLBKDM4ELMNAHPGD | |
| SCHEMBL530191 | 0.77 | ALDH1A1 (0.58) | KDM4EHTTLMNAHPGDALDH1A1 | |
| SCHEMBL30293081 | 0.77 | ALDH1A1 (0.58) | KDM4EHTTLMNAHPGDALDH1A1 | |
| SCHEMBL6764921 | 0.75 | ALDH1A1 (0.57) | TYMSKDM4EHTTHPGDALDH1A1 | |
| SCHEMBL30032319 | 0.73 | CDK4 (0.53) | TYMSPOLBKDM4ELMNAHPGD | |
| SCHEMBL29363212 | 0.73 | CDK4 (0.53) | TYMSPOLBKDM4ELMNAHPGD | |
| SCHEMBL492860 | 0.73 | CDK4 (0.53) | TYMSPOLBKDM4ELMNAHPGD | |
| SCHEMBL20025361 | 0.72 | SMN1; SMN2 (0.56) | TYMSPOLBKDM4EHPGDALDH1A1 | |
| SCHEMBL14843284 | 0.71 | PARP1 (0.49) | KDM4EHTTLMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040101834-A1 | Method of and kit for assessing responsiveness of cancer patients to antifolate chemotherapy | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2004-05-27 | — | — | US | disclosed |