Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759032 | 0.91 | MAPK1 (0.50) | ABCG2MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL6771783 | 0.81 | RAB9A (0.54) | ABCG2MAPTMAPK1RAB9AMEN1 | |
| SCHEMBL6767095 | 0.81 | MAPK1 (0.47) | MAPK1RAB9ASMN1; SMN2PIK3CAMAPK8 | |
| SCHEMBL6772317 | 0.79 | MAPK1 (0.48) | MAPTMAPK1MEN1KMT2APIK3CA | |
| SCHEMBL5762063 | 0.79 | MAPK1 (0.54) | MAPK1RAB9ASMN1; SMN2PIK3CAMAPK8 | |
| SCHEMBL5758412 | 0.79 | MAPK1 (0.48) | MAPTMAPK1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL6762843 | 0.79 | BCHE (0.56) | ABCG2MAPTRAB9AMEN1KMT2A | |
| SCHEMBL5760459 | 0.79 | MAPK8 (0.54) | MAPTMAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL5759348 | 0.77 | MAPK1 (0.53) | MAPTMAPK1RAB9AMEN1KMT2A | |
| SCHEMBL5755458 | 0.76 | AURKA (0.48) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6180631-B1 | PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS IN MAMMALS ASSOCIATED WITH AN ABERRATION IN A SIGNAL TRANSDUCTION PATHWAY SUCH AS CANCER OR A FIBROTIC DISORDER | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2001-01-30 | — | — | US | disclosed |