Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757398 | 0.89 | PIK3CA (0.52) | RAB9ANPC1MEN1KMT2AMAPK1 | |
| SCHEMBL6762843 | 0.88 | BCHE (0.56) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5759348 | 0.85 | MAPK1 (0.53) | RAB9AMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL5760302 | 0.83 | SMN1; SMN2 (0.55) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5757148 | 0.82 | LMNA (0.52) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL6765135 | 0.82 | TP53 (0.50) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL6767084 | 0.82 | PIK3CA (0.49) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL6765225 | 0.81 | ABCG2 (0.50) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5759397 | 0.81 | NPC1 (0.57) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL5761732 | 0.79 | ABCG2 (0.48) | ABCG2MAPK1PIK3CAMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727252-B1 | THE SERINE/THREONINE KINASE FAMILY INCLUDES MEMBERS THAT REGULATE CELL GROWTH, MIGRATION, DIFFERENTIATION, GENE EXPRESSION, MUSCLE CONTRACTION, GLUCOSE METABOLISM, CELLULAR PROTEIN SYNTHESIS, AND REGULATION OF THE CELL CYCLE | ZENTARIS AG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6180631-B1 | PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS IN MAMMALS ASSOCIATED WITH AN ABERRATION IN A SIGNAL TRANSDUCTION PATHWAY SUCH AS CANCER OR A FIBROTIC DISORDER | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 2001-01-30 | — | — | US | disclosed |